Dr. Özlem Yilmaz' laboratory focuses on opportunistic bacteria and host interaction. Her lab is particularly interested in the molecular underpinnings of a major oral pathogen, Porphyromonas gingivalis in evasion of host cell anti-microbial response and survival in the gingival epithelial mucosa using advanced human primary cell systems and transgenic mouse-models. Dr. Yilmaz' lab is one of the a few research teams in the US dedicated to uncovering the complex interplay between host epithelium and periodontopathic bacteria in the induction of microbial dysbiosis and pathophysiology in oral mucosa. Chronic infection by P. gingivalis, an important invasive bacterium, can specifically contribute to a series of severe chronic diseases, including Alzheimer’s disease and orodigestive cancers. Investigating the cellular persistence of this pathogen within host can lead to development of rational treatment strategies for P. gingivalis-associated diseases.
Check Out Our Feature on NIH!
Our work was selected as one of the images in the the NIH Research Image Gallery.
Dr. Yilmaz became an Overseas Fellow of the Royal Society of Medicine, England
Dr. Özlem Yilmaz was honored as an Overseas Fellow of the Royal Society of Medicine, England in 2017. The Society promotes an exchange of information and ideas on science, practice and organisation of medicine.
Ayana Paul graduated PREP, and enters into Emory's PhD Program in Microbiology
Ayana Paul completed her Post-Baccalaureate Research Education Program (PREP) as part of the 2021-2022 cohort, and will pursue her PhD in Microbiology/Molecular Genetics at Emory University.
Bridgette Wellslager was awarded NIH NRSA F31 Pre-Doctoral Grant
Congratulations to Bridgette Wellslager, a PhD Candidate, who was recently awarded the prestigious F31 Predoctoral Individual National Research Service Grant from NIDCR.
Jaden Lee received first place in the 2022 AADOCR Hatton Competition
Jaden Lee, a DMD/PhD candidate, won first place in the AADOCR Hatton Competition for his novel research presentation. He will be presenting at the 2022 IADR Hatton Competition in China.
JoAnn Roberts was awarded NIH NRSA F31 Pre-Doctoral Grant
Congratulations to JoAnn Roberts, a PhD Candidate, who was recently awarded the prestigious F31 Predoctoral Individual National Research Service Grant Award from the NIDCR.
Jaden Lee was consecutively awarded the prestigious AADR Student Research Fellowship
Jaden Lee, a DMD/PhD candidate, has won an AADR STudent Research Award to supplement his current research and travel to the next AADR meetings.
Jaden Lee was awarded NIH NRSA F30 Pre-Doctoral Grant
Congratulations to Jaden Lee, DMD/PhD candidate in our lab! Jaden was recently awarded an NIH F30 Predoctoral Individual National Research Service Award from NIDCR.
Microbes and Infection: Special Issue
In July 2015, Dr. Yilmaz edited a special issue in Microbes and Infection, Institut Pasteur, that focuses on oral pathogens and microbiome in health and disease.
JoAnn Roberts received a scholarship to study redox biology in Karolinska Institutet
JoAnn Roberts, a PhD candidate, was granted a scholarship to study redox biology in Summer 2017 at the Karolinska Institutet in Sweden.
Casey Derieux starts PhD Program in Marine Microbiology at the University of Delaware
Our research specialist, Casey in the Yilmaz Laboratory will be pursuing a PhD in Marine Microbiology at the University of Delaware.
Recent Selected Publications
Patel S, Howard D, Chowdhury N, Derieux C, Wellslager B, Yilmaz O, and French L (2021). Characterization of human genes modulated by Porphyromonas gingivalis highlights the ribosome, hypothalamus, and cholinergic neurons. Front Immunol. 12:646259. doi: 10.3389/fimmu.2021.646259
Lee, JS, Yilmaz, O (2020). Key Elements of Gingival Epithelial Homeostasis upon Bacterial Interaction. Invited Review, Critical Reviews in Oral Biology & Medicine Section. Journal of Dental Res. Nov 17;22034520973012. doi: 10.1177/0022034520973012.
Lee, JS, Chowdhury N, Roberts, JS, and Yilmaz O (2020). Host surface ectonucleotidase-CD73 and the opportunistic pathogen, Porphyromonas gingivalis, cross-modulation underlies a new homeostatic mechanism for chronic bacterial survival in human epithelial cells. Virulence. 11:414-429. doi: 10.1080/21505594.2020.1763061.
Lee J, Spooner R, Chowdhury N, Pandey V, Wellslager B, Atanasova K, Evans Z, Yilmaz O (2020). In Situ Intraepithelial Localizations of Opportunistic Pathogens, Porphyromonas gingivalis and Filifactor alocis, in Human Gingiva. Current Research in Microbial Sciences. 1, 7-17. doi: 10.1016/j.crmicr.2020.05.001.
Olsen I and Yilmaz O (2019). Possible role of Porphyromonas gingivalis in orodigestive cancers. J Oral Microbiol. Jan 9;11(1):1563410. doi: 10.1080/20002297.2018.1563410. eCollection 2019.
Lee K, Roberts JS, Choi C, Atanasova KR, Yilmaz O (2018) Porphyromonas gingivalis Traffics into Endoplasmic Reticulum-Rich-Autophagosomes for Successful Survival in Human Gingival Epithelial Cells, Virulence April 4:1-26. doi:10.1080/21505594.2018.1454171
Lee JN, Roberts JS, Atanasova KR, Chowdhury N and Yilmaz O (2018) A Novel Kinase Function of a Nucleoside-diphosphate-kinase Homolog in P. gingivalis is Critical in Subversion of Host Cell Apoptosis by Targeting Heat-Shock Protein 27, Cellular Microbiology, Jan 22. doi: 10.1111/cmi.1282.